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Acknowledgement: This work was supported by NIDA grant DA022251 to Arthur A. Simen, a pilot grant from the Yale Center for Translational Study of Alcoholism NIAAA grant P50 AA A06377 to Arthur A. Simen, a grant from the Yale Center for Genomics to Arthur A. Simen, a grant from the Conway family to Arthur A. Simen, and NINDS grant 5U24NS051869 to Shrikant M. Mane. The proteomics work was supported by NIA grant DA018343. Elizabeth D. George and Kelly A. Bordner were supported by NIMH grant T32-MH14276. Kelly A. Bordner was also supported by NIA Services grant P01 AG 030004-01A1. Arthur A. Simen was supported by NCRR grant RR024138 and NIA grant AG030970 and a grant from the Yale Pepper Center. Alvaro Duque was supported by NIH grant 2 R01 NS014841-31. The authors wish to acknowledge the support of the Yale Center for High Performance Computation in Biology and Biomedicine and NIH grant RR19895 which funded the computing instrumentation.